The InOrGanoid ANR project—a collaboration between SupBiotech and the Theillet Lab—aims to investigate neurodegenerative diseases using advanced 3D brain organoids derived from human iPSCs. Central to this effort is the integration of in-cell NMR, a breakthrough technique that enables structural and dynamic analysis of biomolecules, particularly proteins, within living cells. Unlike traditional in vitro approaches, in-cell NMR captures molecular behavior in the crowded, dynamic intracellular environment, revealing native conformations, interactions, and dynamics at atomic resolution. Applying this level of detail to complex, physiologically relevant models such as cerebral organoids represents a significant advance in decoding disease mechanisms—bridging the scale from molecule to model.
INORGANOID
Induction and detection of Parkinson's disease in organoids
The InOrGanoid ANR project combines 3D brain organoids and in-cell NMR to study neurodegenerative diseases at atomic resolution in physiologically relevant models. This SupBiotech–Theillet Lab collaboration bridges molecular structure and cellular complexity to decode disease mechanisms.